Synthesis, kinetic study, and reaction mechanism: nucleophilic substitutionreactions of butyl methyl chlorophosphate with substituted anilines anddeuterated substituted anilines in acetonitrile
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چکیده
منابع مشابه
Ruthenium-catalysed synthesis of 2- and 3-substituted quinolines from anilines and 1,3-diols.
A straightforward synthesis of substituted quinolines is described by cyclocondensation of anilines with 1,3-diols. The reaction proceeds in mesitylene solution with catalytic amounts of RuCl(3)·xH(2)O, PBu(3) and MgBr(2)·OEt(2). The transformation does not require any stoichiometric additives and only produces water and dihydrogen as byproducts. Anilines containing methyl, methoxy and chloro s...
متن کاملComputational study of the rate constants and free energies of intramolecular radical addition to substituted anilines
The intramolecular radical addition to aniline derivatives was investigated by DFT calculations. The computational methods were benchmarked by comparing the calculated values of the rate constant for the 5-exo cyclization of the hexenyl radical with the experimental values. The dispersion-corrected PW6B95-D3 functional provided very good results with deviations for the free activation barrier c...
متن کاملKinetic study of the reactions of methyl 2,4,6-trinitrophenyl carbonate with anilines
The title reactions in water are subjected to a kinetic investigation. Under excess amine, pseudofirst-order rate coefficients (kobsd) are obtained. Plots of kobsd against aniline concentration are linear, with kN as the slope. The Brønsted-type plot (log kN vs anilinium pKa) is linear with slope 0.7, consistent with a concerted mechanism. By comparison of these reactions with others, it is con...
متن کاملsingle-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...
15 صفحه اولThe acid-promoted reactions of phenyliodonium ylides with substituted anilines and their applications to the synthesis of indoles.
The N-substituted anilines 1 react readily with phenyliodonium ylides 2 derived from 1,3-dicarbonyl compounds in the presence of a catalytic amount of BF(3).Et(2)O, forming the C-N coupling products 3, which are precursors for the synthesis of indoles. On the basis of this result, the direct synthesis of indoles from 1 and 2 under thermal conditions and photochemical conditions was explored. Th...
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ژورنال
عنوان ژورنال: TURKISH JOURNAL OF CHEMISTRY
سال: 2019
ISSN: 1303-6130
DOI: 10.3906/kim-1807-123